Scientific References

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  • 1.   Everard, A., & Cani, P. D. (2014).Gut microbiota and GLP1. Reviews in endocrine & metabolic disorders, 15(3), 189–196. https://doi.org/10.1007/s11154-014-9288-6

    2.   Liang, L., Su, X., Guan, Y., Wu, B., Zhang, X., & Nian, X. (2024). Correlation between intestinal flora and GLP-1 receptor agonist dulaglutide in type 2 diabetes mellitus treatment-A preliminary longitudinal study. iScience, 27(5), 109784. https://doi.org/10.1016/j.isci.2024.109784

    3.   Singh K, Aulakh SK, Nijjar GS, Singh S, Sandhu APS, Luthra S, Tanvir F, Kaur Y, Singla A, Kaur MS. Rebalancing the Gut: Glucagon-Like Peptide-1 Agonists as a Strategy for Obesity and Metabolic Health. Cureus. 2024 Jul 17;16(7):e64738. doi: 10.7759/cureus.64738. PMID: 39156410; PMCID: PMC11329331.

    4.   Zeng, Y., Wu, Y., Zhang, Q., & Xiao, X. (2024). Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases. mBio, 15(1), e0203223. https://doi.org/10.1128/mbio.02032-23

    5.    Frontiers in Nutrition (2024) shows that personalized diets using microbiome data significantly outperformed standard calorie-based plans for weight loss and GLP-1 stimulation. (https://doi.org/10.3389/fnut.2024.1363079)

    6.   Diabetes, Obesity and Metabolism reported that oligofructose prebiotics raised GLP-1 levels and improved satiety in humans. (https://doi.org/10.1016/j.diabres.2004.12.027)

    7.   Supplementation with A. muciniphila improves insulin sensitivity, reduces inflammation, and enhances metabolic profiles, including GLP-1 levels (Plovier et al., 2017).

    8.   Butyrate has been shown to stimulate GLP-1 release and improve insulin sensitivity (Hatew et al., 2019).

    9.   Dorea spp. are part of metabolic pathways linked with SCFA and indole production, influencing gut-brain signaling.

    10. D. longicatena abundance has been negatively associated with insulin resistance [improves insulin receptor sensitivity] and may modulate gut hormone signaling (de la Cuesta-Zuluaga et al., 2019).

    11. C. minuta has been linked with lower BMI and improved metabolic profiles (Mazier et al., 2021).

    12. “It modulates the gut microbiota, inhibits hepatic lipogenesis, and maintains gut barrier integrity—factors related to GLP-1 signaling and insulin sensitivity.” (Ignatyeva et al., 2024).

    13. E. hallii produces both butyrate and propionate, promoting metabolic health (Engels et al., 2016).

    14. Oral administration improves insulin sensitivity and increases energy expenditure (Udayappan et al., 2016).

    15. GLP-1 analogues reduce hunger and food intake (Näslund et al., 1999).

    16. Butyrate and propionate directly stimulate GLP-1 release (Hatew et al., 2019).\GLP-1 effects on appetite and reward behavior are influenced by insulin sensitivity (Hanssen et al., 2021).

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    • Petrelli F, Oldani S, Borgonovo K, Cabiddu M, Dognini G, Ghilardi M, Parati MC, Petro' D, Dottorini L, Rea C, Lonati V, Luciani A, Ghidini A. Vitamin D3 and COVID-19 Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses. Antioxidants (Basel). 2023 Jan 22;12(2):247. doi: 10.3390/antiox12020247. PMID: 36829806; PMCID: PMC9952713

    • Shahbaz U, Fatima N, Basharat S, Bibi A, Yu X, Hussain MI, Nasrullah M. Role of vitamin C in preventing of COVID-19 infection, progression and severity. AIMS Microbiol. 2022 Mar 30;8(1):108-124. doi: 10.3934/microbiol.2022010. PMID: 35496992; PMCID: PMC8995185.

    

    • Carr AC, Rowe S. The Emerging Role of Vitamin C in the Prevention and Treatment of COVID-19. Nutrients. 2020 Oct 27;12(11):3286. doi: 10.3390/nu12113286. PMID: 33121019; PMCID: PMC7693980.

    • Park J, Park R, Jang M, Park YI. Therapeutic Potential of EGCG, a Green Tea Polyphenol, for Treatment of Coronavirus Diseases. Life (Basel). 2021 Mar 4;11(3):197. doi: 10.3390/life11030197. PMID: 33806274; PMCID: PMC8002208.

    • Oyagbemi AA, Ajibade TO, Aboua YG, Gbadamosi IT, Adedapo ADA, Aro AO, Adejumobi OA, Thamahane-Katengua E, Omobowale TO, Falayi OO, Oyagbemi TO, Ogunpolu BS, Hassan FO, Ogunmiluyi IO, Ola-Davies OE, Saba AB, Adedapo AA, Nkadimeng SM, McGaw LJ, Kayoka-Kabongo PN, Oguntibeju OO, Yakubu MA. Potential health benefits of zinc supplementation for the management of COVID-19 pandemic. J Food Biochem. 2021 Feb;45(2):e13604. doi: 10.1111/jfbc.13604. Epub 2021 Jan 17. PMID: 33458853; PMCID: PMC7995057.

    • Chang SW, Lee HC. Vitamin D and health - The missing vitamin in humans. Pediatr Neonatol. 2019 Jun;60(3):237-244. doi: 10.1016/j.pedneo.2019.04.007. Epub 2019 Apr 17. PMID: 31101452.

    • Knez M, Stangoulis JCR. Dietary Zn deficiency, the current situation and potential solutions. Nutr Res Rev. 2023 Dec;36(2):199-215. doi: 10.1017/S0954422421000342. Epub 2021 Oct 21. PMID: 37062532.

    • Carr AC, Rowe S. Factors Affecting Vitamin C Status and Prevalence of Deficiency: A Global Health Perspective. Nutrients. 2020 Jul 1;12(7):1963. doi: 10.3390/nu12071963. PMID: 32630245; PMCID: PMC7400679.

    • Zhang, Q.; Li, L.; Hao, S.; Liu, M.; Huo, C.; Wu, J.; Liu, H.; Bao, W.; Zheng, H.; Li, Z.; Cheng, H.; Fung, H.; Wong, T.; Leung, P.; Wang, S.; Li, T.; Zhang, G.; Li, M.; Zhao, Z.; Jia, W.; Bian, Z.; Mitchison, T.; Zhang, J.; Lyu, A.; Han, Q.; Sun, H. A Lymphatic Route for a Hyperbranched Heteroglycan from Radix Astragali to Trigger Immune Responses after Oral Dosing. Carbohydr. Polym. 2022, 292, 119653. https://doi.org/10.1016/j.carbpol.2022.119653.

    • Mazziotta C, Tognon M, Martini F, Torreggiani E, Rotondo JC. Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health. Cells. 2023 Jan 2;12(1):184. doi: 10.3390/cells12010184. PMID: 36611977; PMCID: PMC9818925.

    • Kurian SJ, Unnikrishnan MK, Miraj SS, Bagchi D, Banerjee M, Reddy BS, Rodrigues GS, Manu MK, Saravu K, Mukhopadhyay C, Rao M. Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects. Arch Med Res. 2021 Aug;52(6):582-594. doi: 10.1016/j.arcmed.2021.03.002. Epub 2021 Mar 19. PMID: 33785208; PMCID: PMC7972717.Kurian SJ, Unnikrishnan MK, Miraj SS, Bagchi D, Banerjee M, Reddy BS, Rodrigues GS, Manu MK, Saravu K, Mukhopadhyay C, Rao M. Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects. Arch Med Res. 2021 Aug;52(6):582-594. doi: 10.1016/j.arcmed.2021.03.002. Epub 2021 Mar 19. PMID: 33785208; PMCID: PMC7972717.

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    Hongli Wang, Yueshu Cai, Wenqi Wu, Miaomiao Zhang, Yong Dai, Qingwen Wang,Exploring the role of gut microbiome in autoimmune diseases: A comprehensive review,Autoimmunity Reviews,

    Volume 23, Issue 12,2024,103654,ISSN 1568-9972,

    https://doi.org/10.1016/j.autrev.2024.103654.

    (https://www.sciencedirect.com/science/article/pii/S1568997224001459)

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    Xuan Zhang, Bei-di Chen, Li-dan Zhao, Hao Li,

    The Gut Microbiota: Emerging Evidence in Autoimmune Diseases,

    Trends in Molecular Medicine,

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    2020,

    Pages 862-873,

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